Improving Lives By Protecting Hearing
Spiral is advancing a therapeutic pipeline with focus on balance disorders and hearing loss. Our lead program, SPT-2101, is a sustained-release steroid formulation for the treatment of Ménière’s disease.

About
40 million people in the US qualify for hearing loss treatment, but there are no drugs approved for hearing loss. Drug delivery to the inner ear remains the largest obstacle.
Precise, non-invasive placement techniques, combined with long-acting delivery systems have the potential to overcome the barriers of drug delivery to the inner ear.
Inflammation and neurodegeneration are the origin of 90% of inner ear disorders. Biomarkers of active disease and improved patient selection are necessary to overcome the challenges of clinical development.
Inspired by ophthalmology, Spiral’s platform addresses hearing loss by delivering the right drugs, to the right place, for the right duration. Our novel drug delivery platform allows for minimally invasive, precise and durable exposure of drugs to the cochlea.
Spiral is advancing a therapeutic pipeline with focus on balance disorders and hearing loss. Our lead program, SPT-2101, is a sustained-release steroid formulation for the treatment of Ménière’s disease.
Team
Executive Team
Board of Directors

Hugo Peris
FOUNDER & CEO

Angela Macfarlane
INDEPENDENT

Guy Jean Savoir
SAVOIR CAPITAL

Tony Adamis
INDEPENDENT

Eugene de Juan
EXECUTIVE CHAIRMAN

Fred Guerard
INDEPENDENT

Diamantis Xylas
CATALIO CAPITAL
Technology
Our precise delivery platform is uniquely suited to deliver a wide range of drugs to the ear. We have developed formulations that have the potential to achieve months of residence in the middle ear. These formulations allow us to deliver drugs with anti-inflammatory and neuroprotective effects for the treatment of balance disorders and hearing loss.

Ménière's disease
Ménière’s disease is a chronic condition characterized by acute vertigo attacks, tinnitus, fluctuating hearing loss and a feeling of aural fullness. Of these symptoms, the vertigo attacks are typically most troubling for patients since they disrupt daily activities and are difficult to anticipate and manage. In general, patients are diagnosed with unilateral Ménière’s disease in middle age and symptoms often continue for decades. Over time, the fluctuating hearing loss becomes permanent in many patients, and a subset of patients will develop symptoms in their second ear. According to the National Institute of Deafness and Other Communication Disorders, there are more than 600,000 patients diagnosed with Ménière’s disease in the United States. There is no known cure for Ménière’s disease and there are currently no FDA-approved drug treatments.
Our lead program, SPT-2101, is currently the subject of an investigational clinical trial in Australia for the treatment of Ménière’s disease. Early data from this trial is showing significant improvement in the frequency of patient reported vertigo episodes and other efficacy outcome measures.
News
Spiral Therapeutics Acquires Otonomy Assets to Boost Inner Ear Disorders Pipeline and Appoints Industry Leaders to Board
Spiral Therapeutics acquires assets from Otonomy, including data, patent rights, and inventory related
Spiral Therapeutics Announces SPT-2101 Presentation at the 15th ASOHNS Congress in Brisbane, Australia
SOUTH SAN FRANCISCO, Calif., Mar. 06, 2023 -- Spiral Therapeutics, Inc. (“Spiral”), a
Spiral Therapeutics Announces Poster Presentation at Association for Research in Otolaryngology Annual Meeting
SOUTH SAN FRANCISCO, Calif., Feb. 06, 2023 -- Spiral Therapeutics, Inc. (“Spiral”), a