Spiral Therapeutics

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MICS™ Minimally Invasive Cochlear System

MICS delivers our local formulations to the inner ear, with each formulation matched to its drug substance.Designed for the ENT office, not the operating room.

How MICS works

Precise delivery, in the clinic

Until now, physicians had to choose between delivering a drug blind in the clinic or precisely in the operating room. MICS brings precise delivery into the clinic.

Today

Office injection

Performed blind. The physician cannot confirm where the drug ends up.

  • Precise placement No
  • Performed in the clinic Yes
Today

Surgery

Precise placement, but it requires an operating room.

  • Precise placement Yes
  • Performed in the clinic No
Spiral

MICS™

Precise placement of our local formulations under direct visualization, in a routine office visit.

  • Precise placement Yes
  • Performed in the clinic Yes
Versatility

One system across drug classes

MICS places the right drug at the right target. Each drug substance is paired with a formulation suited to it, so the same system works with small molecules, proteins and advanced therapies.

The platform

MICS™ + formulations tailored to each drug

OFHOOHOOH Dexamethasone · 392 Da
Protein · ~25 kDa
AAV gene therapy · ~4 MDa

Small molecules

Formulations of approved and novel agents, including our most advanced program.

SPT-2101 · SPT-5108

Proteins

Neurotrophins and other biologics, where formulation and local exposure are the bottleneck.

SPT-4106

Advanced therapies

Gene and cell therapies, where precise delivery matters most.

In evaluation
Why it matters

Access is what has held the field back

The biology of inner ear disease is better understood than ever, and promising molecules exist. What has been missing is a reliable way to place enough drug at the inner ear. MICS and our local formulations are designed to address that, so more inner ear therapies can reach patients.

See our pipeline